Ultra-short-acting Relaxants

The use of short-acting relaxants in E.C.T.

SINCE the introduction of curare to modify the contractions in E.C.T. , the use of relaxants has become standard psychiatric practice. These substances reduce the risk of fractures and enable treatment to be given to patients who would other wise be denied it owing to risks arising from concomitant physical disease. During recent years great efforts have been made to simplify the technique of m...

Thiazolodiazepines: New Ultra-short Acting Hypnotics

The synthesis and hypnotic evaluation of a new generation of thiazolo[3,2-a][1,3]diazepine analogs are described. Those compounds exhibit potent in vivo activities as ultra-short acting hypnotics. Background of the Invention Surgical procedures require the administration of several intravenous drugs to ensure hypnosis, analgesia, relaxation and control of visceral reflex responses. The use of i...

Thiazolodiazepines: New Ultra-short Acting Hypnotics

The synthesis and hypnotic evaluation of a new generation of thiazolo[3,2-a][1,3]diazepine analogs are described. Those compounds exhibit potent in vivo activities as ultra-short acting hypnotics. Background of the Invention Surgical procedures require the administration of several intravenous drugs to ensure hypnosis, analgesia, relaxation and control of visceral reflex responses. The use of i...

pain management in intensive care unit patients: the role of ultra-short acting opioid: remifentanil

Pain Management in Intensive Care Unit Patients: The Role of Ultra-Short Acting Opioid: Remifentanil

Implication for health policy/practice/research/medical education: Pain management in the intensive care unit is a neglected issue and has not been hitherto addressed. This editorial would dwell on the issue of pain management and the potential role of remifentanil in the ICU setting. which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is pr...